Healthy and Unhealthy Cardiac Progenitor Cells Modify the Pathogenesis of Myocardial Diseases
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چکیده
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a life-threatening inherited cardiomyopathy with an estimated prevalence of 1 per 5000 individuals characterized by the replacement of the cardiac myocytes with fibrofatty tissue leading to ventricular arrhythmias, right ventricular failure, and sudden cardiac death. ARVD/C is commonly inherited in an autosomal dominant manner with an incomplete penetrance and variable expressivity caused by mutations in desmosomal genes (eg, plakoglobin, plakophilin-2, desmoplakin, desmoglein-2, and desmocollin-2) and several nondesmosomal genes (such as ryanodine receptor, phospholamban, transmembrane protein 43, titin, and TGFβ3).
منابع مشابه
Healthy and Unhealthy Cardiac Progenitor Cells Modify the Pathogenesis of Myocardial Diseases.
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a life-threatening inherited cardiomyopathy with an estimated prevalence of 1 per 5000 individuals characterized by the replacement of the cardiac myocytes with fibrofatty tissue leading to ventricular arrhythmias, right ventricular failure, and sudden cardiac death. ARVD/C is commonly inherited in an autosomal dominant manne...
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